Advancement in Nanostructure-Based Tissue-Engineered Biomaterials for Retinal Degenerative Diseases

0545156 - ÚŽFG 2022 RIV CH eng J - Článek v odborném periodiku
Rohiwal, Sonali Suresh - Ellederová, Zdeňka - Ardan, Taras - Klíma, Jiří
Advancement in Nanostructure-Based Tissue-Engineered Biomaterials for Retinal Degenerative Diseases.
Biomedicines. Roč. 9, č. 8 (2021), č. článku 1005. E-ISSN 2227-9059
Grant CEP: GA ČR(CZ) GA18-04393S; GA ČR(CZ) GC19-09628J; GA TA ČR(CZ) TO01000107
Institucionální podpora: RVO:67985904
Klíčová slova: nanostructures * cell transplantation * retinal degenerative disease
Obor OECD: Health-related biotechnology
Impakt faktor: 4.757, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/2227-9059/9/8/1005

The review intends to overview a wide range of nanostructured natural, synthetic and biological membrane implants for tissue engineering to help in retinal degenerative diseases. Herein, we discuss the transplantation strategies and the new development of material in combination with cells such as induced pluripotent stem cells (iPSC), mature retinal cells, adult stem cells, retinal progenitors, fetal retinal cells, or retinal pigment epithelial (RPE) sheets, etc. to be delivered into the subretinal space. Retinitis pigmentosa and age-related macular degeneration (AMD) are the most common retinal diseases resulting in vision impairment or blindness by permanent loss in photoreceptor cells. Currently, there are no therapies that can repair permanent vision loss, and the available treatments can only delay the advancement of retinal degeneration. The delivery of cell-based nanostructure scaffolds has been presented to enrich cell survival and direct cell differentiation in a range of retinal degenerative models. In this review, we sum up the research findings on different types of nanostructure scaffolds/substrate or material-based implants, with or without cells, used to deliver into the subretinal space for retinal diseases. Though, clinical and pre-clinical trials are still needed for these transplants to be used as a clinical treatment method for retinal degeneration.
Trvalý link: http://hdl.handle.net/11104/0321908