Počet záznamů: 1  

Meis homeobox genes control progenitor competence in the retina

  1. 1.
    0544817 - ÚMG 2022 RIV US eng J - Článek v odborném periodiku
    Dupačová, Naoko - Antošová, Barbora - Pačes, Jan - Kozmik, Zbyněk
    Meis homeobox genes control progenitor competence in the retina.
    Proceedings of the National Academy of Sciences of the United States of America. Roč. 118, č. 12 (2021), č. článku e2013136118. ISSN 0027-8424
    Grant CEP: GA ČR(CZ) GA18-20759S; GA MŠk(CZ) LQ1604; GA MŠk(CZ) LM2018126; GA MŠk ED2.1.00/19.0395; GA MŠk(CZ) ED1.1.00/02.0109
    Institucionální podpora: RVO:68378050
    Klíčová slova: retina * Meis * development
    Obor OECD: Cell biology
    Impakt faktor: 12.779, rok: 2021
    Způsob publikování: Omezený přístup
    https://www.pnas.org/content/118/12/e2013136118

    The vertebrate eye is derived from the neuroepithelium, surface ectoderm, and extracellular mesenchyme. The neuroepithelium forms an optic cup in which the spatial separation of three domains is established, namely, the region of multipotent retinal progenitor cells (RPCs), the ciliary margin zone (CMZ)-which possesses both a neurogenic and nonneurogenic potential-and the optic disk (OD), the interface between the optic stalk and the neuroretina. Here, we show by genetic ablation in the developing optic cup that Meis1 and Meis2 homeobox genes function redundantly to maintain the retinal progenitor pool while they simultaneously suppress the expression of genes characteristic of CMZ and OD fates. Furthermore, we demonstrate that Meis transcription factors bind regulatory regions of RPC-, CMZ-, and OD-specific genes, thus providing a mechanistic insight into the Meis-dependent gene regulatory network. Our work uncovers the essential role of Meis1 and Meis2 as regulators of cell fate competence, which organize spatial territories in the vertebrate eye.
    Trvalý link: http://hdl.handle.net/11104/0321624

     
     
Počet záznamů: 1