Počet záznamů: 1
Biological performances of plasmonic biohybrids based on phyto-silver/silver chloride nanoparticles
- 1.0544174 - ÚMCH 2022 RIV CH eng J - Článek v odborném periodiku
Gorshkova, Y. - Barbinta-Patrascu, M.-E. - Bokuchava, G. - Badea, N. - Ungureanu, C. - Lazea-Stoyanova, A. - Raileanu, M. - Bacalum, M. - Turchenko, V. - Zhigunov, Alexander - Juszyńska-Galazka, E.
Biological performances of plasmonic biohybrids based on phyto-silver/silver chloride nanoparticles.
Nanomaterials. Roč. 11, č. 7 (2021), č. článku 1811. E-ISSN 2079-4991
Grant ostatní: Committee for collaboration of Czech Republic with Joint Institute for Nuclear Research in Dubna(RU) 04-4-1121
Institucionální podpora: RVO:61389013
Klíčová slova: silver/silver chloride nanoparticles * “green” synthesis * chlorophyll-a-labeled bio-inspired membranes
Obor OECD: Polymer science
Impakt faktor: 5.719, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/2079-4991/11/7/1811
Silver/silver chloride nanoparticles (Ag/AgClNPs), with a mean size of 48.2 ± 9.5 nm and a zeta potential value of −31.1 ± 1.9 mV, obtained by the Green Chemistry approach from a mixture of nettle and grape extracts, were used as “building blocks” for the “green” development of plasmonic biohybrids containing biomimetic membranes and chitosan. The mechanism of biohybrid formation was elucidated by optical analyses (UV–vis absorption and emission fluorescence, FTIR, XRD, and SAXS) and microscopic techniques (AFM and SEM). The aforementioned novel materials showed a free radical scavenging capacity of 75% and excellent antimicrobial properties against Escherichia coli (IGZ = 45 mm) and Staphylococcus aureus (IGZ = 35 mm). The antiproliferative activity of biohybrids was highlighted by a therapeutic index value of 1.30 for HT-29 cancer cells and 1.77 for HepG2 cancer cells. At concentrations below 102.2 µM, these materials are not hemolytic, so they will not be harmful when found in the bloodstream. In conclusion, hybrid systems based on phyto-Ag/AgClNPs, artificial cell membranes, and chitosan can be considered potential adjuvants in liver and colorectal cancer treatment.
Trvalý link: http://hdl.handle.net/11104/0321225
Počet záznamů: 1