Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors

0544146 - ÚMG 2022 RIV US eng J - Článek v odborném periodiku
Lassi, M. - Tomar, A. - Comas-Armangue, G. - Vogtmann, R. - Dijkstra, D.J. - Corujo, D. - Gerlini, R. - Darr, J. - Scheid, F. - Rozman, Jan - Aguilar-Pimentel, A. - Koren, O. - Buschbeck, M. - Fuchs, H. - Marschall, S. - Gailus-Durner, V. - de Angelis, M.H. - Plosch, T. - Gellhaus, A. - Teperino, R.
Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors.
Science Advances. Roč. 7, č. 22 (2021), č. článku eabg6424. ISSN 2375-2548. E-ISSN 2375-2548
Institucionální podpora: RVO:68378050
Klíčová slova: fetal-growth * sex-differences * glucocorticoids * clocks * mouse * restriction * obesity * responses * hormones * stress
Obor OECD: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Impakt faktor: 14.980, rok: 2021
Způsob publikování: Open access
https://advances.sciencemag.org/content/7/22/eabg6424

Circadian rhythm synchronizes each body function with the environment and regulates physiology. Disruption of normal circadian rhythm alters organismal physiology and increases disease risk. Recent epidemiological data and studies in model organisms have shown that maternal circadian disruption is important for offspring health and adult phenotypes. Less is known about the role of paternal circadian rhythm for offspring health. Here, we disrupted circadian rhythm in male mice by night-restricted feeding and showed that paternal circadian disruption at conception is important for offspring feeding behavior, metabolic health, and oscillatory transcription. Mechanistically, our data suggest that the effect of paternal circadian disruption is not transferred to the offspring via the germ cells but initiated by corticosterone-based parental communication at conception and programmed during in utero development through a state of fetal growth restriction. These findings indicate paternal circadian health at conception as a newly identified determinant of offspring phenotypes.
Trvalý link: http://hdl.handle.net/11104/0321186