A cellular and spatial map of the choroid plexus across brain ventricles and ages

0544117 - ÚMG 2022 RIV US eng J - Článek v odborném periodiku
Dani, N. - Herbst, R.H. - McCabe, C. - Green, G.S. - Kaiser, K. - Head, J.P. - Cui, J. - Shipley, F.B. - Jang, A. - Dionne, D. - Nguyen l, L. - Rodman, C. - Riesenfeld, S.J. - Procházka, Jan - Procházková, Michaela - Sedláček, Radislav - Zhang, F. - Bryja, V. - Rozenblatt-Rosen, O. - Habib, N. - Regev, A. - Lehtinen, M.K.
A cellular and spatial map of the choroid plexus across brain ventricles and ages.
Cell. Roč. 184, č. 11 (2021), s. 3056-3074. ISSN 0092-8674. E-ISSN 1097-4172
Grant CEP: GA MŠMT(CZ) LM2018129; GA MŠMT ED2.1.00/19.0395; GA MŠMT(CZ) LM2018126; GA MŠMT EF16_013/0001789
Institucionální podpora: RVO:68378050
Klíčová slova: gene-expression * rhombic lip * roof plate * spi-c * barrier * differentiation * inflammation * macrophages * recruitment * activation
Obor OECD: Developmental biology
Impakt faktor: 66.850, rok: 2021
Způsob publikování: Omezený přístup
https://www.cell.com/cell/fulltext/S0092-8674(21)00438-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867421004384%3Fshowall%3Dtrue

The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. We delineate diverse cell types, subtypes, cell states, and expression programs in epithelial and mesenchymal cells across ages and ventricles. In the developing ChP, we predict a common progenitor pool for epithelial and neuronal cells, validated by lineage tracing. Epithelial and fibroblast cells show regionalized expression by ventricle, starting at embryonic stages and persisting with age, with a dramatic transcriptional shift with maturation, and a smaller shift in each aged cell type. With aging, epithelial cells upregulate host-defense programs, and resident macrophages upregulate interleukin-1 beta (IL-1 beta) signaling genes. Our atlas reveals cellular diversity, architecture and signaling across ventricles during development, maturation, and aging of the ChP-brain barrier.
Trvalý link: http://hdl.handle.net/11104/0321167