Počet záznamů: 1  

Role of Cell Death in Cellular Processes During Odontogenesis

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    0544014 - ÚŽFG 2022 RIV CH eng J - Článek v odborném periodiku
    Abramyan, A. - Geetha-Loganathan, P. - Šulcová, Marie - Buchtová, Marcela
    Role of Cell Death in Cellular Processes During Odontogenesis.
    Frontiers in Cell and Developmental Biology. Roč. 9, JUN 18 (2021), č. článku 671475. ISSN 2296-634X. E-ISSN 2296-634X
    Grant CEP: GA MŠMT EF15_003/0000460
    Institucionální podpora: RVO:67985904
    Klíčová slova: teeth * dental lamina * apoptosis
    Obor OECD: Developmental biology
    Impakt faktor: 6.081, rok: 2021
    Způsob publikování: Open access
    https://www.frontiersin.org/articles/10.3389/fcell.2021.671475/full

    The development of a tooth germ in a precise size, shape, and position in the jaw, involves meticulous regulation of cell proliferation and cell death. Apoptosis, as the most common type of programmed cell death during embryonic development, plays a number of key roles during odontogenesis, ranging from the budding of the oral epithelium during tooth initiation, to later tooth germ morphogenesis and removal of enamel knot signaling center. Here, we summarize recent knowledge about the distribution and function of apoptotic cells during odontogenesis in several vertebrate lineages, with a special focus on amniotes (mammals and reptiles). We discuss the regulatory roles that apoptosis plays on various cellular processes during odontogenesis. We also review apoptosis-associated molecular signaling during tooth development, including its relationship with the autophagic pathway. Lastly, we cover apoptotic pathway disruption, and alterations in apoptotic cell distribution in transgenic mouse models. These studies foster a deeper understanding how apoptotic cells affect cellular processes during normal odontogenesis, and how they contribute to dental disorders, which could lead to new avenues of treatment in the future.
    Trvalý link: http://hdl.handle.net/11104/0321079

     
     
Počet záznamů: 1  

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