2-Hydroxyethyl methacrylate hydrogels for local drug delivery: study of topotecan and vincristine sorption/desorption kinetics and polymer-drug interaction by ATR-FTIR spectroscopy

0543672 - ÚMCH 2022 RIV DE eng J - Článek v odborném periodiku
Cocarta, Ana-Irina - Hobzová, Radka - Trchová, Miroslava - Svojgr, K. - Kodetova, M. - Pochop, P. - Uhlík, J. - Širc, Jakub
2-Hydroxyethyl methacrylate hydrogels for local drug delivery: study of topotecan and vincristine sorption/desorption kinetics and polymer-drug interaction by ATR-FTIR spectroscopy.
Macromolecular Chemistry and Physics. Roč. 222, č. 13 (2021), č. článku 2100086. ISSN 1022-1352. E-ISSN 1521-3935
Grant CEP: GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109
Grant ostatní: AV ČR(CZ) StrategieAV21/10
Program: StrategieAV
Institucionální podpora: RVO:61389013
Klíčová slova: hydrogel * HEMA * topotecan
Obor OECD: Polymer science
Impakt faktor: 2.996, rok: 2021
Způsob publikování: Omezený přístup
https://onlinelibrary.wiley.com/doi/10.1002/macp.202100086

Poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels are well known in ophthalmological applications and recently investigated as drug delivery systems. The study represents a theoretical approach where the sorption/desorption experiments and spectroscopic study is used to describe the influence of the pHEMA network structure on the sorption capacity and mechanism of the release of topotecan (TPT) and vincristine (VCR). The hydrogels are synthesized by free-radical crosslinking polymerization of HEMA monomer with ethylene glycol dimethacrylate as a crosslinker in the concentration range from 0.3 to 1 wt%. Experimental data from sorption kinetics are evaluated using sorption kinetic models and sorption isotherms, drug release mechanism is assessed by two different models and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy is employed to describe the polymer-drug interaction. pHEMA hydrogels exhibit higher affinity for TPT than for VCR and hydrogels prepared with 0.5 wt% of crosslinker show the maximum sorption capacity for both drugs. Physisorption is proved to be the sorption mechanism. Analyzing the FTIR spectra, it is concluded that the hydrophobic crosslinks play an important role in the interaction of the hydrogel backbone with molecules of both drugs.
Trvalý link: http://hdl.handle.net/11104/0321232