Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

0543092 - MBÚ 2022 RIV NL eng J - Článek v odborném periodiku
Vinarov, Z. - Abrahamsson, B. - Artursson, P. - Batchelor, H. - Berben, P. - Bernkop-Schnurch, A. - Butler, J. - Ceulemans, J. - Davies, N. - Dupont, D. - Flaten, G. E. - Fotaki, N. - Griffin, B. T. - Jannin, V. - Keemink, J. - Kesisoglou, F. - Koziolek, M. - Kuentz, M. - Mackie, A. - Melendez-Martinez, A. J. - McAllister, M. - Mullertz, A. - O'Driscoll, C. M. - Parrott, N. - Paszkowska, J. - Pávek, P. - Porter, C. J. H. - Reppas, C. - Stillhart, C. - Sugano, K. - Toader, E. - Valentová, Kateřina - Vertzoni, M. - De Wildt, S. N. - Wilson, C. G. - Augustijns, P.
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network.
Advanced Drug Delivery Reviews. Roč. 171, APR 2021 (2021), s. 289-331. ISSN 0169-409X. E-ISSN 1872-8294
Grant CEP: GA MŠMT(CZ) LTC19039; GA MŠMT(CZ) LTC18003; GA ČR(CZ) GA18-00132S
Institucionální podpora: RVO:61388971
Klíčová slova: Specific patient populations * Regional differences * Advanced formulations * Amorphous solid dispersions * Lipid-based formulations * Food-drug interactions * Microbiome * In vitro tools * PBPK modeling
Obor OECD: Pharmacology and pharmacy
Impakt faktor: 17.873, rok: 2021
Způsob publikování: Open access
https://www.sciencedirect.com/science/article/pii/S0169409X21000351?via%3Dihub

Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.
Trvalý link: http://hdl.handle.net/11104/0320380