Počet záznamů: 1
Transient Inactivation of the Medial Prefrontal Cortex and Ventral Hippocampus Impairs Active Place Avoidance Retrieval on a Rotating Arena
- 1.0542617 - FGÚ 2022 RIV CH eng J - Článek v odborném periodiku
Černotová, Daniela - Stuchlík, Aleš - Svoboda, Jan
Transient Inactivation of the Medial Prefrontal Cortex and Ventral Hippocampus Impairs Active Place Avoidance Retrieval on a Rotating Arena.
Frontiers in Neural Circuits. Roč. 15, 28 Apr (2021), č. článku 634533. ISSN 1662-5110. E-ISSN 1662-5110
Grant CEP: GA MZd NV17-30833A; GA MZd(CZ) NU20-04-00389; GA ČR(CZ) GA20-00939S
Grant ostatní: AV ČR(CZ) PAN-20-08
Program: Bilaterální spolupráce
Institucionální podpora: RVO:67985823
Klíčová slova: spatial memory * muscimol * hippocampo-prefrontal pathway * active place avoidance * rotating arena
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 3.342, rok: 2021
Způsob publikování: Open access
https://doi.org/10.3389/fncir.2021.634533
It is well known that communication between the medial prefrontal cortex (mPFC) and the ventral hippocampus (vHPC) is critical for various cognitive and behavioral functions. However, the exact role of these structures in spatial coordination remains to be clarified. Here we sought to determine the involvement of the mPFC and the vHPC in the spatial retrieval of a previously learned active place avoidance task in adult male Long-Evans rats, using a combination of unilateral and bilateral local muscimol inactivations. Moreover, we tested the role of the vHPC-mPFC pathway by performing combined ipsilateral and contralateral inactivations. Our results showed not only bilateral inactivations of either structure, but also the combined inactivations impaired the retrieval of spatial memory, whereas unilateral one-structure inactivations did not yield any effect. Remarkably, muscimol injections in combined groups exerted similar deficits, regardless of whether the inactivations were contralateral or ipsilateral. These findings confirm the importance of these structures in spatial cognition and emphasize the importance of the intact functioning of the vHPC-mPFC pathway.
Trvalý link: http://hdl.handle.net/11104/0320000
Počet záznamů: 1