Potent Cyclic Tetrapeptide for Lead Detoxification

0542235 - ÚOCHB 2022 RIV DE eng J - Článek v odborném periodiku
Mohammed, T. A. - Meier, C. M. - Kalvoda, Tadeáš - Kalt, M. - Rulíšek, Lubomír - Shoshan, M. S.
Potent Cyclic Tetrapeptide for Lead Detoxification.
Angewandte Chemie - International Edition. Roč. 60, č. 22 (2021), s. 12381-12385. ISSN 1433-7851. E-ISSN 1521-3773
Grant CEP: GA ČR(CZ) GA20-08772S
Institucionální podpora: RVO:61388963
Klíčová slova: chelation therapy * lead poisoning * metal selectivity * peptides * rational design
Obor OECD: Physical chemistry
Impakt faktor: 16.823, rok: 2021
Způsob publikování: Omezený přístup
https://doi.org/10.1002/anie.202103217

Lead (Pb) is a ubiquitous poisonous metal, affecting the health of vast populations worldwide. Medications to treat Pb poisoning suffer from various limitations and are often toxic owing to insufficient metal selectivity. Here, we report a cyclic tetrapeptide that selectively binds Pb and eradicates its toxic effect on the cellular level, with superior potency than state‐of‐the‐art drugs. The Pb‐peptide complex is remarkably strong and was characterized experimentally and computationally. Accompanied by the lack of toxicity and enhanced stability of this peptide, these qualities indicate its merit as a potential remedy for Pb poisoning.
Trvalý link: http://hdl.handle.net/11104/0319700