A Paradigm Revolution or Just Better Resolution-Will Newly Emerging Superresolution Techniques Identify Chromatin Architecture as a Key Factor in Radiation-Induced DNA Damage and Repair Regulation?

0542166 - BFÚ 2022 RIV CH eng J - Článek v odborném periodiku
Falk, Martin - Hausmann, M.
A Paradigm Revolution or Just Better Resolution-Will Newly Emerging Superresolution Techniques Identify Chromatin Architecture as a Key Factor in Radiation-Induced DNA Damage and Repair Regulation?
Cancers (Basel). Roč. 13, č. 1 (2021), č. článku 18. E-ISSN 2072-6694
Grant CEP: GA ČR GC20-04109J; GA ČR(CZ) GA19-09212S
Institucionální podpora: RVO:68081707
Klíčová slova: double-strand-break * human transcriptome map * complex cell responses * homologous recombination * ionizing-radiation * pathway choice
Obor OECD: Oncology
Impakt faktor: 6.575, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/2072-6694/13/1/18

Radiation-induced double-strand breaks (DSBs) are the most toxic and most difficult to repair DNA lesions and are very heterogeneous. These characteristics place considerable demands on the selection of the most suitable repair mechanism at each individual damage site. Here, we review the current knowledge on this still enigmatic process and hypothesize that it critically involves the local chromatin architecture at the micro- and nanoscales, later manifested in the architecture of DSB repair foci (i.e., IRIFs).
Trvalý link: http://hdl.handle.net/11104/0319644