The rDNA Loci-Intersections of Replication, Transcription, and Repair Pathways

0542084 - BFÚ 2022 RIV CH eng J - Článek v odborném periodiku
Goffová, I. - Fajkus, Jiří
The rDNA Loci-Intersections of Replication, Transcription, and Repair Pathways.
International Journal of Molecular Sciences. Roč. 22, č. 3 (2021), č. článku 1302. E-ISSN 1422-0067
Grant CEP: GA MŠMT EF15_003/0000477
Institucionální podpora: RVO:68081707
Klíčová slova: rDNA organization * genome stability * rRNA genes * ribosome * caf-1 * rad51 * rtel1
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 6.208, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/1422-0067/22/3/1302

Genes encoding ribosomal RNA (rDNA) are essential for cell survival and are particularly sensitive to factors leading to genomic instability. Their repetitive character makes them prone to inappropriate recombinational events arising from collision of transcriptional and replication machineries, resulting in unstable rDNA copy numbers. In this review, we summarize current knowledge on the structure and organization of rDNA, its role in sensing changes in the genome, and its linkage to aging. We also review recent findings on the main factors involved in chromatin assembly and DNA repair in the maintenance of rDNA stability in the model plants Arabidopsis thaliana and the moss Physcomitrella patens, providing a view across the plant evolutionary tree.
Trvalý link: http://hdl.handle.net/11104/0319574