Počet záznamů: 1
Residues flanking the ARK(me3)T/S motif allow binding of diverse targets to the HP1 chromodomain: Insights from molecular dynamics simulations
- 1.0542005 - BFÚ 2022 RIV NL eng J - Článek v odborném periodiku
Pokorná, Pavlína - Krepl, Miroslav - Šponer, Jiří
Residues flanking the ARK(me3)T/S motif allow binding of diverse targets to the HP1 chromodomain: Insights from molecular dynamics simulations.
Biochimica et Biophysica Acta-General Subjects. Roč. 1865, č. 1 (2021), č. článku 129771. ISSN 0304-4165. E-ISSN 1872-8006
Grant CEP: GA ČR(CZ) GA18-07384S
Institucionální podpora: RVO:68081707
Klíčová slova: heterochromatin protein-1 hp1 * force-field parameters * histone h3 * lysine 9 * secondary structure * structural basis
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 4.117, rok: 2021
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S0304416520302828?via%3Dihub
Background: The chromodomain (CD) of HP1 proteins is an established H3K9(me3) reader that also binds H1, EHMT2 and H3K23 lysine-methylated targets. Structural experiments have provided atomistic pictures of its recognition of the conserved ARK(me3)S/T motif, but structural dynamics' contribution to the recognition may have been masked by ensemble averaging.
Trvalý link: http://hdl.handle.net/11104/0319504
Počet záznamů: 1