Počet záznamů: 1
Polysubstituted pyrimidines inhibiting the formation of prostaglandin E2, a method of production thereof and use thereof
- 1.0541997 - ÚOCHB 2022 RIV eng P - Patentový dokument
Kolman, Viktor - Kalčic, Filip - Janeba, Zlatko - Zídek, Zdeněk
Polysubstituted pyrimidines inhibiting the formation of prostaglandin E2, a method of production thereof and use thereof.
2020. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. - Ústav experimentální medicíny AV ČR, v. v. i. Datum udělení patentu: 22.10.2020. Číslo patentu: AU2018273599
Grant CEP: GA TA ČR(CZ) TE01020028
Institucionální podpora: RVO:61388963 ; RVO:68378041
Klíčová slova: pyrimidines * anti-inflammatory * prostaglandin E2 synthase
Obor OECD: Organic chemistry; Medicinal chemistry (UEM-P)
https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20201022&DB=&locale=en_EP&CC=AU&NR=2018273599B2&KC=B2&ND=4
The invention describes the pyrimidine-based compounds of the general formula I. Described compounds lower the production of the prostaglandin E2. In concentrations lowering production of this factor by 50%, these compounds have no negative effect on the cell viability and they are not cytotoxic. Furthermore, the method of production of the compounds of the general formula I is provided. A pharmaceutical composition comprising the polysubstituted pyrimidines according to the invention and the use of these compounds for the treatment of the inflammatory diseases are also provided.
Trvalý link: http://hdl.handle.net/11104/0319499
Počet záznamů: 1