グルタミン類似体のプロドラッグ

0541959 - ÚOCHB 2022 RIV jpn P - Patentový dokument
Slusher, B. - Rais, R. - Tenora, Lukáš - Majer, Pavel - Jančařík, Andrej
グルタミン類似体のプロドラッグ.
[Prodrugs of glutamine analogs.]
2021. Vlastník: The Johns Hopkins University. - Ústav organické chemie a biochemie AV ČR, v. v. i. Datum udělení patentu: 21.04.2021. Číslo patentu: JP6863981
Institucionální podpora: RVO:61388963
Klíčová slova: 6-diazo-5-oxo-L-norleucine (DON) * prodrugs * cancer
Obor OECD: Organic chemistry
https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20210421&DB=&locale=en_EP&CC=JP&NR=6863981B2&KC=B2&ND=5

グルタミン類似体のプロドラッグ、例えば、アザ-セリンのプロドラッグ、6-ジアゾ-5-オキソ-ノルロイシン(DON)のプロドラッグ、および5-ジアゾ-4-オキソ-L-ノルバリン(L-DONV)のプロドラッグが開示される。

The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). The disclosure also provides compounds having formula (I) for use in treating cancer.
Trvalý link: http://hdl.handle.net/11104/0319470