Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: multilocation analysis in 398 cities

0541838 - ÚFA 2022 RIV GB eng J - Článek v odborném periodiku
Meng, X. - Liu, C. - Chen, R. - Sera, F. - Vicedo-Cabrera, A.M. - Milojevic, A. - Guo, Y. - Tong, S. - Coelho, M. S. Z. S. - Saldiva, P. H. N. - Lavigne, E. - Correa, P.M. - Ortega, N. V. - Garcia, S.O. - Kyselý, Jan - Urban, Aleš - Orru, H. - Maasikmets, M. - Jaakkola, J.J.K. - Ryti, N. - Huber, V. - Schneider, A. - Katsouyanni, K. - Analitis, A. - Hashizume, M. - Honda, Y. - Ng, Ch.F.S. - Nunes, B. - Teixeira, J. P. - Holobaca, I.H. - Fratianni, S. - Kim, H. - Tobias, A. - Iniguez, C. - Forsberg, B. - Åström, C. - Ragettli, M.S. - Guo, Y. L. L. - Pan, S.-Ch. - Li, S. - Bell, M.L. - Zanobetti, A. - Schwartz, J. - Wu, T. - Gasparrini, A. - Kan, H.
Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: multilocation analysis in 398 cities.
British medical journal. Roč. 372, MAR 24 (2021), č. článku n534. ISSN 1756-1833. E-ISSN 1756-1833
Grant CEP: GA ČR(CZ) GA18-22125S
Institucionální podpora: RVO:68378289
Klíčová slova: carbon monoxide * nitrogen dioxide * ozone * sulfur dioxide * nitrogen dioxide
Obor OECD: Meteorology and atmospheric sciences
Impakt faktor: 96.216, rok: 2021
Způsob publikování: Open access
https://www.bmj.com/content/372/bmj.n534

Objective: To evaluate the short term associations between nitrogen dioxide (NO 2) and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide, using a uniform analytical protocol. Design: Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis. Setting: 398 cities in 22 low to high income countries/regions. Main outcome measures: Daily deaths from total (62.8 million), cardiovascular (19.7 million), and respiratory (5.5 million) causes between 1973 and 2018. Results: On average, a 10 μg/m 3 increase in NO 2 concentration on lag 1 day (previous day) was associated with 0.46% (95% confidence interval 0.36% to 0.57%), 0.37% (0.22% to 0.51%), and 0.47% (0.21% to 0.72%) increases in total, cardiovascular, and respiratory mortality, respectively. These associations remained robust after adjusting for co-pollutants (particulate matter with aerodynamic diameter ≤10 μm or ≤2.5 μm (PM 10 and PM 2.5, respectively), ozone, sulfur dioxide, and carbon monoxide). The pooled concentration-response curves for all three causes were almost linear without discernible thresholds. The proportion of deaths attributable to NO 2 concentration above the counterfactual zero level was 1.23% (95% confidence interval 0.96% to 1.51%) across the 398 cities. Conclusions This multilocation study provides key evidence on the independent and linear associations between short term exposure to NO 2 and increased risk of total, cardiovascular, and respiratory mortality, suggesting that health benefits would be achieved by tightening the guidelines and regulatory limits of NO 2.
Trvalý link: http://hdl.handle.net/11104/0319350