0541774 - FZÚ 2022 RIV US eng J - Článek v odborném periodiku
Zablotskii, Vitalii - Polyakova, Tetyana - Dejneka, Alexandr
Modulation of the cell membrane potential and intracellular protein transport by high magnetic fields.
Bioelectromagnetics. Roč. 42, č. 1 (2021), s. 27-36. ISSN 0197-8462. E-ISSN 1521-186X
Grant CEP: GA MŠMT(CZ) EF16_019/0000760
Grant ostatní: OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institucionální podpora: RVO:68378271
Klíčová slova: cell responses to magnetic fields * membrane potential * ion diffusion * magnetogenetics * diffusiophoresis
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 1.848, rok: 2021
Způsob publikování: Omezený přístup
https://doi.org/10.1002/bem.22309

To explore cellular responses to high magnetic fields (HMF), we present a model of the interactions of cells with a homogeneous HMF that accounts for the magnetic force exerted on paramagnetic/diamagnetic species. There are various chemical species inside a living cell, many of which may have large concentration gradients. Thus, when an HMF is applied to a cell, the concentration-gradient magnetic forces act on paramagnetic or diamagnetic species and can either assist or oppose large particle movement through the cytoplasm. We demonstrate possibilities for changing the machinery in living cells with HMFs and predict two new mechanisms for modulating cellular functions with HMFs via (i) changes in the membrane potential and (ii) magnetically assisted intracellular diffusiophoresis of large proteins. By deriving a generalized form for the Nernst equation, we find that an HMF can change the membrane potential of the cell and thus have a significant impact on the properties and biological functionality of cells. The elaborated model provides a universal framework encompassing current studies on controlling cell functions by high static magnetic fields. Bioelectromagnetics.
Trvalý link: http://hdl.handle.net/11104/0322347