Odontoblast TRPC5 channels signal cold pain in teeth

0541625 - FGÚ 2022 RIV US eng J - Článek v odborném periodiku
Bernal, L. - Sotelo-Hitschfeld, P. - König, Ch. - Sinica, Viktor - Wyatt, A. - Winter, Z. - Hein, A. - Touška, Filip - Reinhardt, S. - Tragl, A. - Kusuda, R. - Wartenberg, P. - Sclaroff, A. - Pfeifer, J. D. - Ectors, F. - Dahl, A. - Freichel, M. - Vlachová, Viktorie - Brauchi, S. - Roza, C. - Boehm, U. - Clapham, D. E. - Lennerz, J. K. - Zimmermann, K.
Odontoblast TRPC5 channels signal cold pain in teeth.
Science Advances. Roč. 7, č. 13 (2021), č. článku eabf5567. ISSN 2375-2548. E-ISSN 2375-2548
Institucionální podpora: RVO:67985823
Klíčová slova: Transient Receptor Potential (TRP) channel * TRPC5 * TRPA1 * TRPM8 * odontoblast * cold transduction * primary cold sensory cell
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 14.980, rok: 2021
Způsob publikování: Open access
https://advances.sciencemag.org/content/7/13/eabf5567

Teeth are composed of many tissues, covered by an inflexible and obdurate enamel. Unlike most other tissues, teeth become extremely cold sensitive when inflamed. The mechanisms of this cold sensation are not understood. Here, we clarify the molecular and cellular components of the dental cold sensing system and show that sensory transduction of cold stimuli in teeth requires odontoblasts. TRPC5 is a cold sensor in healthy teeth and, with TRPA1, is sufficient for cold sensing. The odontoblast appears as the direct site of TRPC5 cold transduction and provides a mechanism for prolonged cold sensing via TRPC5’s relative sensitivity to intracellular calcium and lack of desensitization. Our data provide concrete functional evidence that equipping odontoblasts with the cold-sensor TRPC5 expands traditional odontoblast functions and renders it a previously unknown integral cellular component of the dental cold sensing system.
Trvalý link: http://hdl.handle.net/11104/0319158