Perampanel exhibits anticonvulsant action against pentylentetrazol-induced seizures in immature rats

0541569 - FGÚ 2022 RIV NL eng J - Článek v odborném periodiku
Mareš, Pavel - Kubová, Hana
Perampanel exhibits anticonvulsant action against pentylentetrazol-induced seizures in immature rats.
Epilepsy Research. Roč. 169, Jan (2021), č. článku 106523. ISSN 0920-1211. E-ISSN 1872-6844
Grant CEP: GA MŠMT(CZ) LH15032; GA ČR(CZ) GA18-09296S; GA MZd(CZ) EF16_025/0007444
Institucionální podpora: RVO:67985823
Klíčová slova: perampanel * AMPA receptors * pentylenetetrazol * rat * postnatal development
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 2.991, rok: 2021
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.eplepsyres.2020.106523

Perampanel is a new antiepileptic drug with unique mechanism of action - antagonism of AMPA receptors. Its action in immature animals is not yet sufficiently known therefore we started to study anticonvulsant action of perampanel pretreatment (1-20 mg/kg i.p.) against seizures elicited by pentylenetetrazol. Three age groups of rats were examined - 12, 18 and 25 days old. Perampanel selectively suppressed the tonic phase of generalized seizures in the two younger groups and whole tonic-clonic seizures in the 25-day-old group. It exhibited also an anticonvulsant action against minimal clonic seizures present in control 18- and 25-day-old rats.
Trvalý link: http://hdl.handle.net/11104/0319108