Optical sensors of heterotrimeric G protein signaling

0540889 - ÚOCHB 2022 RIV GB eng J - Článek v odborném periodiku
Bondar, Alexey - Lazar, Josef
Optical sensors of heterotrimeric G protein signaling.
FEBS Journal. Roč. 288, č. 8 (2021), s. 2570-2584. ISSN 1742-464X. E-ISSN 1742-4658
Grant CEP: GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LTAIN19167
Institucionální podpora: RVO:61388963
Klíčová slova: BRET * FRET * G protein * G protein-coupled receptor * imaging * optogenetics * polarization microscopy * sensor * single‐molecule imaging * TIRF
Obor OECD: Physical chemistry
Impakt faktor: 5.622, rok: 2021
Způsob publikování: Omezený přístup
https://doi.org/10.1111/febs.15655

Heterotrimeric G proteins are central mediators of cellular signal transduction. They receive, process, and transduce signals from G protein‐coupled receptors to downstream effectors. Since their discovery, a number of optical sensors of G protein localisation and function have been developed and applied in living systems. In this minireview, we provide an overview of existing G protein‐based sensors and the experimental approaches they utilise, with emphasis on live‐cell imaging techniques. We outline recent advances, as well as identify current challenges and likely future directions in the field of G protein sensor development.
Trvalý link: http://hdl.handle.net/11104/0318492