The need to unravel the twisted nature of the Borrelia burgdorferi sensu lato complex across Europe

0540547 - BC 2021 RIV GB eng J - Článek v odborném periodiku
Strnad, Martin - Rego, Ryan O. M.
The need to unravel the twisted nature of the Borrelia burgdorferi sensu lato complex across Europe.
Microbiology. Roč. 166, č. 5 (2020), s. 428-435. ISSN 1350-0872. E-ISSN 1465-2080
Grant CEP: GA ČR(CZ) GA17-21244S
Institucionální podpora: RVO:60077344
Klíčová slova: lyme-disease spirochete * whole-genome sequences * outer surface protein * decorin-binding * reporter system * gene-expression * salivary-glands * sp-nov * afzelii * tick * Lyme borreliosis * Europe vs North America * tick * genetic manipulations * Borrelia diversity
Obor OECD: Microbiology
Impakt faktor: 2.777, rok: 2020
Způsob publikování: Omezený přístup
https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000899

Lyme borreliosis is a vector-borne infection caused by bacteria under the Borrelia burgdorferi sensu lato complex, both in Europe and North America. Differential gene expression at different times throughout its infectious cycle allows the spirochete to survive very diverse environments within different mammalian hosts as well as the tick vector. To date, the vast majority of data about spirochetal proteins and their functions are from genetic studies carried out on North American strains of a single species, i.e. B. burgdorferi sensu stricto. The whole-genome sequences recently obtained for several European species/strains make it feasible to adapt and use genetic techniques to study inherent differences between them. This review highlights the crucial need to undertake independent studies of genospecies within Europe, given their varying genetic content and pathogenic potential, and differences in clinical manifestation.
Trvalý link: http://hdl.handle.net/11104/0318173