The actin regulator profilin 1 is functionally associated with the mammalian centrosome

0540121 - ÚMG 2023 RIV US eng J - Článek v odborném periodiku
Nejedlá, M. - Klebanovych, Anastasiya - Sulimenko, Vadym - Sulimenko, Tetyana - Dráberová, Eduarda - Dráber, Pavel - Karlsson, R.
The actin regulator profilin 1 is functionally associated with the mammalian centrosome.
Life Science Alliance. Roč. 4, č. 1 (2021), č. článku e202000655. E-ISSN 2575-1077
Grant CEP: GA ČR(CZ) GA18-27197S; GA MŠMT(CZ) LM2018129
Institucionální podpora: RVO:68378050
Klíčová slova: profilin * centrosome * microtubule nucleation
Obor OECD: Cell biology
Impakt faktor: 5.781, rok: 2021
Způsob publikování: Open access
https://www.life-science-alliance.org/content/4/1/e202000655

Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation.
Trvalý link: http://hdl.handle.net/11104/0317777