Maghemite nanoparticles coated by methacrylamide-based polymer for magnetic particle imaging

0539851 - ÚMCH 2022 RIV NL eng J - Článek v odborném periodiku
Herynek, V. - Babič, Michal - Kaman, Ondřej - Charvátová, Hana - Veselá, M. - Buchholz, O. - Vosmanská, M. - Kubániová, D. - Kohout, J. - Hofmann, U. G. - Šefc, L.
Maghemite nanoparticles coated by methacrylamide-based polymer for magnetic particle imaging.
Journal of Nanoparticle Research. Roč. 23, č. 2 (2021), č. článku 52. ISSN 1388-0764. E-ISSN 1572-896X
Grant CEP: GA ČR GA19-02584S; GA MŠMT(CZ) LQ1604
Výzkumná infrastruktura: Czech-BioImaging II - 90129
Institucionální podpora: RVO:61389013 ; RVO:68378271
Klíčová slova: maghemite nanoparticles * superparamagnetic iron oxide * magnetic particle imaging
Obor OECD: Polymer science; Nano-materials (production and properties) (FZU-D)
Impakt faktor: 2.533, rok: 2021
Způsob publikování: Open access
https://link.springer.com/article/10.1007/s11051-021-05164-x

A wise selection of tracers is critical for magnetic particle imaging (MPI). Most of the current tracers are based on superparamagnetic iron oxide nanoparticles (SPIONs) with a suitable coating. We prepared maghemite cores (γ-Fe2O3) by coprecipitation of Fe(II) and Fe(III) salts with ammonium hydroxide followed by oxidation with hydrogen peroxide and stabilization as an anionic (γ-Fe2O3⊖) or cationic colloid (γ-Fe2O3⨁). The cores were coated by poly(N-(2-hydroxypropyl)methacrylamide)-co-N-[2-(hydroxyamino)-2-oxo-ethyl]-2-methyl-prop-2-enamide. The particles were characterized by dynamic light scattering, transmission electron microscopy, X-ray diffraction, Mössbauer spectroscopy, tested in vitro in a field-free point MPI scanner, and compared to nanoparticles prepared by oxidation with sodium hypochlorite and to the commercially available Resovist®. The cores had an average diameter of 8.0 nm (γ-Fe2O3⨁) and 8.7 nm (γ-Fe2O3⊖). The hydrodynamic diameter was 88 nm. Zeta potential values for both positively charged (+52 mV) and negatively charged particles (–60 mV) provided for good colloidal stabilization. Spinel structure of maghemite was confirmed by Mössbauer spectroscopy. The uncoated γ-Fe2O3⨁ particles yielded an MPI signal lower (by 16 %) than Resovist. The coated ones reached 88 % of the Resovist signal. Anionic γ-Fe2O3⊖ particles reached a higher (uncoated particles, by 15 %) or comparable (coated ones) signal relative to Resovist with a substantially lower signal dispersion. Control particles prepared by oxidation with sodium hypochlorite scored the weakest results. To conclude, a suitable size, narrow size distribution, and colloidal stability predispose the synthetized particles for use as a tracer for MPI. The anionic particles provided a higher signal with a lower dispersion than commercial tracers.
Trvalý link: http://hdl.handle.net/11104/0318618