Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain

0539602 - ÚEM 2021 RIV US eng J - Článek v odborném periodiku
De Santis, S. - Cosa-Linan, A. - Garcia-Hernandez, R. - Dmytrenko, Lesia - Vargová, Lýdia - Voříšek, I. - Stopponi, S. - Bach, P. - Kirsch, P. - Kiefer, F. - Ciccocioppo, R. - Syková, E. - Moratal, D. - Sommer, W.H. - Canals, S.
Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain.
Science Advances. Roč. 6, č. 26 (2020), č. článku eaba0154. ISSN 2375-2548. E-ISSN 2375-2548
Grant CEP: GA ČR(CZ) GA16-10214S
Institucionální podpora: RVO:68378041
Klíčová slova: rat nucleus-accumbens * dopamine uptake * in-vivo
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 14.143, rok: 2020
Způsob publikování: Open access
https://advances.sciencemag.org/content/6/26/eaba0154

Already moderate alcohol consumption has detrimental long-term effects on brain function. However, how alcohol produces its potent addictive effects despite being a weak reinforcer is a poorly understood conundrum that likely hampers the development of successful interventions to limit heavy drinking. In this translational study, we demonstrate widespread increased mean diffusivity in the brain gray matter of chronically drinking humans and rats. These alterations appear soon after drinking initiation in rats, persist into early abstinence in both species, and are associated with a robust decrease in extracellular space tortuosity explained by a microglial reaction. Mathematical modeling of the diffusivity changes unveils an increased spatial reach of extrasynaptically released transmitters like dopamine that may contribute to alcohol's progressively enhanced addictive potency.
Trvalý link: http://hdl.handle.net/11104/0317310