Molecular Aspects of the Development and Function of Auditory Neurons

0538962 - BTÚ 2021 RIV CH eng J - Článek v odborném periodiku
Pavlínková, Gabriela
Molecular Aspects of the Development and Function of Auditory Neurons.
International Journal of Molecular Sciences. Roč. 22, č. 1 (2021), č. článku 131. E-ISSN 1422-0067
Grant CEP: GA ČR(CZ) GA20-06927S
Institucionální podpora: RVO:86652036
Klíčová slova: embryonic stem-cells * spiral ganglion neurons * inner-ear * cochlear innervation * auditory pathways * genetic mutations
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 6.208, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/1422-0067/22/1/131

This review provides an up-to-date source of information on the primary auditory neurons or spiral ganglion neurons in the cochlea. These neurons transmit auditory information in the form of electric signals from sensory hair cells to the first auditory nuclei of the brain stem, the cochlear nuclei. Congenital and acquired neurosensory hearing loss affects millions of people worldwide. An increasing body of evidence suggest that the primary auditory neurons degenerate due to noise exposure and aging more readily than sensory cells, and thus, auditory neurons are a primary target for regenerative therapy. A better understanding of the development and function of these neurons is the ultimate goal for long-term maintenance, regeneration, and stem cell replacement therapy. In this review, we provide an overview of the key molecular factors responsible for the function and neurogenesis of the primary auditory neurons, as well as a brief introduction to stem cell research focused on the replacement and generation of auditory neurons.
Trvalý link: http://hdl.handle.net/11104/0318193