Handbook of Innovations in Central Nervous System Regenerative Medicine

0538920 - ÚEM 2021 RIV NL eng M - Část monografie knihy
Kárová, Kristýna - Machová-Urdzíková, Lucia - Romanyuk, Nataliya - Svobodová, Barbora - Kekulová, Kristýna - Kočí, Zuzana - Jendelová, Pavla - Kubinová, Šárka
Chapter 8 - Tissue engineering and regenerative medicine in spinal cord injury repair.
Handbook of Innovations in Central Nervous System Regenerative Medicine. Amsterdam: Elsevier, 2020 - (Salgado, A.), s. 291-332. ISBN 978-0-12-818084-6
Grant CEP: GA MŠMT(CZ) EF15_003/0000419; GA ČR(CZ) GA17-03765S; GA ČR(CZ) GA17-11140S; GA ČR(CZ) GA19-10365S; GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT(CZ) LQ1604
Institucionální podpora: RVO:68378041
Klíčová slova: spinal cord injury * regenerative medicine * cell therapy
Obor OECD: Neurosciences (including psychophysiology
https://www.sciencedirect.com/science/article/pii/B9780128180846000088?via%3Dihub

Spinal cord injury (SCI) is a devastating trauma that often leads to a permanent loss of motor and sensory functions, pain, and spasticity. A functional repair of injured tissue in the adult central nervous system remains a major issue for current biomedical research and its advancing clinical translation. Regenerative medicine, together with tissue engineering and various interdisciplinary methods, may offer new approaches to reduce neuronal death, glial scars at the injury site, and induce axonal regeneration. In this review we introduce SCI, its pathophysiology, available experimental models, and behavioral testing, which have been used for its further study. We also provide a comprehensive overview of selected experimental approaches based on cell transplantation, antioxidative treatment, laser therapy, biomaterial scaffolds, and their combinations. Finally, we consider the future direction of spinal neuromodulation research such as electrical stimulation or molecular manipulation, which could overcome molecular barriers inhibiting axonal growth to promote regeneration.
Trvalý link: http://hdl.handle.net/11104/0317706