Evolution and Natural History of Membrane Trafficking in Eukaryotes

0538887 - BC 2021 RIV GB eng J - Článek v odborném periodiku
More, K. - Klinger, C.M. - Barlow, L.D. - Dacks, Joel Bryan
Evolution and Natural History of Membrane Trafficking in Eukaryotes.
Current Biology. Roč. 30, č. 10 (2020), R553-R564. ISSN 0960-9822. E-ISSN 1879-0445
Institucionální podpora: RVO:60077344
Klíčová slova: clathrin-mediated endocytosis * comparative genomics * toxoplasma-gondii * life-cycle * complex * protein * system * coat * syntaxin * acidocalcisomes
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 10.834, rok: 2020
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/abs/pii/S0960982220304401?via%3Dihub

The membrane-trafficking system is a defining facet of eukaryotic cells. The best-known organelles and major protein families of this system are largely conserved across the vast diversity of eukaryotes, implying both ancient organization and functional unity. Nonetheless, intriguing variation exists that speaks to the evolutionary forces that have shaped the endomembrane system in eukaryotes and highlights ways in which membrane trafficking in protists differs from that in our well-understood models of mammalian and yeast cells. Both parasites and free-living protists possess specialized trafficking organelles, some lineage specific, others more widely distributed the evolution and function of these organelles begs exploration. Novel members of protein families are present across eukaryotes but have been lost in humans. These proteins may well hold clues to understanding differences in cellular function in organisms that are of pressing importance for planetary health.
Trvalý link: http://hdl.handle.net/11104/0316632