Isolation of the antibacterial alkaloid distichamine from Crossyne Salisb. (Amaryllidaceae: Amaryllideae: Strumariinae)

0538790 - ÚOCHB 2022 RIV ZA eng J - Článek v odborném periodiku
Naidoo, D. - Manning, J.C. - Slavětínská, Lenka - Van Staden, J.
Isolation of the antibacterial alkaloid distichamine from Crossyne Salisb. (Amaryllidaceae: Amaryllideae: Strumariinae).
South African Journal of Botany. Roč. 137, Mar (2021), s. 331-334. ISSN 0254-6299. E-ISSN 1727-9321
Institucionální podpora: RVO:61388963
Klíčová slova: chemotaxonomy * Amaryllidaceae * alkaloid * distichamine * anticancer
Obor OECD: Analytical chemistry
Impakt faktor: 3.111, rok: 2021
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.sajb.2020.10.011

Isoquinoline alkaloids of the Amaryllidaceae have proven to be of significant value in drug discovery and development. Crossyne guttata is frequently used in traditional medicine as an antiseptic and wound cleaner as well as to treat alcoholism. The aim of the study was to identify the variation in alkaloid content of the species in relation to published works on the genus Boophone. We isolated Distichamine 1 from an ethanolic fraction of Crossyne guttata using column chromatography. Spectroscopic analysis yielded three alkaloids, distichamine 1, crinamine 2 and epibuphanisine 3. Distichamine 1 is a rare β-crinane alkaloid previously isolated only from the genus Boophone. The presence of distichamine 1 in the genus Crossyne suggests that it may be more widespread in tribe Amaryllideae than originally thought.
Trvalý link: http://hdl.handle.net/11104/0316961