Pentamethinium salts as ligands for cancer: Sulfated polysaccharide co-receptors as possible therapeutic target

0538135 - ÚMG 2021 RIV US eng J - Článek v odborném periodiku
Bříza, T. - Králová, Jarmila - Rimpelová, S. - Havlík, M. - Kaplánek, R. - Kejik, Z. - Martásek, P. - Mikula, I. - Dzubak, P. - Hajduch, M. - Ruml, T. - Král, V.
Pentamethinium salts as ligands for cancer: Sulfated polysaccharide co-receptors as possible therapeutic target.
Bioorganic Chemistry. Roč. 82, February (2019), s. 74-85. ISSN 0045-2068. E-ISSN 1090-2120
Grant CEP: GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:68378050
Klíčová slova: Anticancer activity * Cytotoxicity * Fluorescent cyanine * Pentamethinium salt * Recognition * Sulfated polysaccharides
Obor OECD: Cell biology
Impakt faktor: 4.831, rok: 2019
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/abs/pii/S0045206817306934?via%3Dihub

A series of pentamethinium salts with benzothiazolium and indolium side units comprising one or two positive charges were designed and synthesized to determine the relationships among the molecular structure, charge density, affinity to sulfated polysaccharides, and biological activity. Firstly, it was found that the affinity of the pentamethinium salts to sulfated polysaccharides correlated with their biological activity. Secondly, the side heteroaromates displayed a strong effect on the cytotoxicity and selectivity towards cancer cells. Finally, doubly charged pentamethinium salts possessing benzothiazolium side units exhibited remarkably high efficacy against a taxol-resistant cancer cell line. (C) 2018 Published by Elsevier Inc.
Trvalý link: http://hdl.handle.net/11104/0315958