RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription

0538114 - ÚMG 2021 RIV CH eng J - Článek v odborném periodiku
Andrš, Martin - Hašanová, Zdeňka - Oravetzová, Anna - Dobrovolná, Jana - Janščák, Pavel
RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription.
Genes. Roč. 11, č. 2 (2020), č. článku 232. E-ISSN 2073-4425
Grant CEP: GA ČR GA19-07674S; GA MŠMT LTAUSA19096; GA MŠMT(CZ) EF16_013/0001775
Institucionální podpora: RVO:68378050
Klíčová slova: recq5 * transcription-replication conflicts * replication stress * R-loops * DNA repair * genomic instability
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 4.096, rok: 2020
Způsob publikování: Open access
https://www.mdpi.com/2073-4425/11/2/232

RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice. Human RECQ5 is known for its ability to regulate homologous recombination by disrupting RAD51 nucleoprotein filaments. It also binds to RNA polymerase II (RNAPII) and negatively regulates transcript elongation by RNAPII. Here, we summarize recent studies implicating RECQ5 in the prevention and resolution of transcription-replication conflicts, a major intrinsic source of genomic instability during cancer development.
Trvalý link: http://hdl.handle.net/11104/0315941