Kilohertz macromolecular crystallography using an EIGER detector at low X-ray fluxes

0537905 - FZÚ 2021 RIV CH eng J - Článek v odborném periodiku
Khakurel, Krishna - Espinoza Herrera, Shirly J. - Savko, M. - Polovinkin, Vitaly - Dohnálek, Jan - Shepard, W. - Angelova, A. - Hajdu, Janos - Andreasson, Jakob - Angelov, Borislav
Kilohertz macromolecular crystallography using an EIGER detector at low X-ray fluxes.
Crystals. Roč. 10, č. 12 (2020), s. 1-14, č. článku 1146. ISSN 2073-4352. E-ISSN 2073-4352
Grant CEP: GA MŠMT EF16_019/0000789; GA MŠMT EF15_003/0000447
Grant ostatní: OP VVV - ADONIS(XE) CZ.02.1.01/0.0/0.0/16_019/0000789; OP VVV - ELIBIO(XE) CZ.02.1.01/0.0/0.0/15_003/0000447
Výzkumná infrastruktura: ELI Beamlines III - 90141
Institucionální podpora: RVO:68378271 ; RVO:86652036
Klíčová slova: in-house ultrafast macromolecular X-ray crystallography * Eiger X 1M detector * fast X-ray diffraction data acquisition
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.); Analytical chemistry (BTO-N)
Impakt faktor: 2.589, rok: 2020
Způsob publikování: Open access

Time-resolved in-house macromolecular crystallography is primarily limited by the capabilities of the in-house X-ray sources. These sources can only provide a time-averaged structure of the macromolecules. A significant effort has been made in the development of in-house laser-driven ultrafast X-ray sources, with one of the goals as realizing the visualization of the structural dynamics of macromolecules at a very short timescale within the laboratory-scale infrastructure. Most of such in-house ultrafast X-ray sources are operated at high repetition rates and usually deliver very low flux. Therefore, the necessity of a detector that can operate at the repetition rate of the laser and perform extremely well under low flux conditions is essential.
Trvalý link: http://hdl.handle.net/11104/0315742