.sup.1./sup.H, .sup.13./sup.C and .sup.15./sup.N NMR of spiro acridines integrated with pyrrole scaffolds

0537827 - FZÚ 2021 RIV US eng J - Článek v odborném periodiku
Vilková, M. - Šoral, M. - Bečka, M. - Potočňák, I. - Sabolová, D. - Béres, T. - Dušek, Michal - Imrich, J.
¹H, ¹³C and ¹⁵N NMR of spiro acridines integrated with pyrrole scaffolds.
Magnetic Resonance in Chemistry. Roč. 58, č. 2 (2020), s. 204-214. ISSN 0749-1581. E-ISSN 1097-458X
Grant CEP: GA MŠMT(CZ) LO1603
GRANT EU: European Commission(CZ) CZ.2.16/3.1.00/24510
Institucionální podpora: RVO:68378271
Klíčová slova: acridines * pyrrole scaffolds * antiviral * antibacterial * X-ray crystallography * crystal structure
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 2.447, rok: 2020
Způsob publikování: Omezený přístup
https://doi.org/10.1002/mrc.4974

Acridines are important organic compounds with potent biological properties, which are in focus of our longterm research. The hydrazide–hydrazone fragment CH=N-NH-CO represents a significant structural unit with a wide range of biological activities such as antitumor, antimicrobial, anti‐inflammatory, and antituberculotic. The use of acridine derivatives in the synthesis of hydrazide–hydrazones has seemed favorable to us because of their interesting antiviral, antibacterial, and antitumor properties. In connection with our ongoing studies on the new acridine derivatives, we decided to prepare compounds containing both hydrazide–hydrazone and acridine substructures for utilization in the synthesis of heterocycles.

Trvalý link: http://hdl.handle.net/11104/0315662