Počet záznamů: 1  

Synthesis, characterization and in vitro evaluation of anticancer activity of a new water-soluble thiosemicarbazone ligand and its complexes

  1. 1.
    0537815 - FZÚ 2021 RIV GB eng J - Článek v odborném periodiku
    Sardroud, S.J. - Hosseini-Yazdi, S.A. - Mahdavi, M. - Poupon, Morgane - Skořepová, Eliška
    Synthesis, characterization and in vitro evaluation of anticancer activity of a new water-soluble thiosemicarbazone ligand and its complexes.
    Polyhedron. Roč. 175, Jan (2020), s. 1-10, č. článku 114218. ISSN 0277-5387. E-ISSN 1873-3719
    Grant CEP: GA MŠMT(CZ) LO1603; GA ČR(CZ) GA18-10504S
    GRANT EU: European Commission(CZ) CZ.2.16/3.1.00/24510
    Institucionální podpora: RVO:68378271
    Klíčová slova: apoptosis * cell cycle * cytotoxicity * flow cytometry * Schiff base * thiosemicarbazone
    Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
    Impakt faktor: 3.052, rok: 2020
    Způsob publikování: Omezený přístup
    https://doi.org/10.1016/j.poly.2019.114218

    A new water-soluble thiosemicarbazone ligand, 4-hydroxyl-3-({[(methylamino)carbonothioyl] hydrazono}methyl)benzoic acid (H3LCOOH) and its complexes with Cu(II), Ni(II), Zn(II), Fe(III) and Mn(III) were synthesized and characterized. These compounds were characterized by conductivity, magnetic susceptibility, elemental analysis, FT-IR, 1H NMR, 13C NMR, and UV–Vis spectroscopy. All the complexes significantly showed more anticancer activity than the ligand alone and the Cu(II) complex showed considerable cytotoxicity against the tested cell lines.
    Trvalý link: http://hdl.handle.net/11104/0315650

     
     
Počet záznamů: 1  

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