Počet záznamů: 1  

Natural feed additives modulate immunity and mitigate infection with sphaerospora molnari (Myxozoa:Cnidaria) in common carp: A pilot study

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    0537376 - BC 2021 RIV CH eng J - Článek v odborném periodiku
    Ganeva, Vyara Ognyanova - Korytář, Tomáš - Pecková, Hana - McGurk, C. - Mullins, J. - Yanes-Roca, C. - Gela, D. - Lepič, P. - Policar, T. - Holzer, Astrid S.
    Natural feed additives modulate immunity and mitigate infection with sphaerospora molnari (Myxozoa:Cnidaria) in common carp: A pilot study.
    Pathogens. Roč. 9, č. 12 (2020), s. 1-11, č. článku 1013. E-ISSN 2076-0817
    Institucionální podpora: RVO:60077344
    Klíčová slova: Adaptive immunity * Curcumin * Fish * In-feed * Innate immunity * Parasite * Yeast
    Obor OECD: Veterinary science
    Impakt faktor: 3.492, rok: 2020
    Způsob publikování: Open access
    https://www.mdpi.com/2076-0817/9/12/1013

    Licensee MDPI, Basel, Switzerland. Myxozoans are a diverse group of cnidarian parasites, including important pathogens in different aquaculture species, without effective legalized treatments for fish destined for human consumption. We tested the effect of natural feed additives on immune parameters of common carp and in the course of a controlled laboratory infection with the myxozoan Sphaerospora molnari. Carp were fed a base diet enriched with 0.5% curcumin or 0.12% of a multi-strain yeast fraction, before intraperitoneal injection with blood stages of S. molnari. We demonstrate the impact of these treatments on respiratory burst, phagocytosis, nitric oxide production, adaptive IgM+ B cell responses, S. molnari-specific antibody titers, and on parasite numbers. Both experimental diets enriched B cell populations prior to infection and postponed initial parasite proliferation in the blood. Curcumin-fed fish showed a decrease in reactive oxygen species, nitric oxide production and B cell density at late-stage infection, likely due to its anti-inflammatory properties, favoring parasite propagation. In contrast, multi-strain yeast fraction (MsYF)-fed fish harbored the highest S. molnari-specific antibody titer, in combination with the overall lowest parasite numbers. The results demonstrate that yeast products can be highly beneficial for the outcome of myxozoan infections and could be used as effective feed additives in aquaculture.
    Trvalý link: http://hdl.handle.net/11104/0315092

     
     
Počet záznamů: 1  

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