Critical analysis of non-thermal plasma-driven modulation of immune cells from clinical perspective

0537371 - FZÚ 2021 RIV CH eng J - Článek v odborném periodiku
Smolková, Barbora - Frtús, Adam - Uzhytchak, Mariia - Lunova, Mariia - Kubinová, Šárka - Dejneka, Alexandr - Lunov, Oleg
Critical analysis of non-thermal plasma-driven modulation of immune cells from clinical perspective.
International Journal of Molecular Sciences. Roč. 21, č. 17 (2020), s. 1-24, č. článku 6226. E-ISSN 1422-0067
Grant CEP: GA MPO(CZ) FV10081; GA MŠMT(CZ) EF16_019/0000760
Grant ostatní: OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institucionální podpora: RVO:68378271
Klíčová slova: non-thermal plasma * cytotoxicity * cell signaling * immunomodulation
Obor OECD: Biophysics
Impakt faktor: 5.924, rok: 2020
Způsob publikování: Open access

The emerged field of non-thermal plasma shows great potential in the alteration of cell redox status, which can be utilized as a promising therapeutic implication. In recent years, the NTP field considerably progresses in the modulation of immune cell function leading to promising in vivo results. In fact, understanding the underlying cellular mechanisms triggered by NTP remains incomplete. In order to boost the field closer to real-life clinical applications, there is a need for a critical overview of the current state-of-the-art. In this review, we conduct a critical analysis of the NTP-triggered modulation of immune cells. Importantly, we analyze pitfalls in the field and identify persisting challenges. We show that the identification of misconceptions opens a door to the development of a research strategy to overcome these limitations. Finally, we propose the idea that solving problems highlighted in this review will accelerate the clinical translation of NTP-based treatments.
Trvalý link: http://hdl.handle.net/11104/0315086