Počet záznamů: 1  

Genetic Diversity of Serine Protease Inhibitors in Myxozoan (Cnidaria, Myxozoa) Fish Parasites

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    0537340 - BC 2021 RIV CH eng J - Článek v odborném periodiku
    Eszterbauer, E. - Sipos, D. - Szego, D. - Fiala, Ivan - Holzer, Astrid S. - Bartošová-Sojková, Pavla … celkem 7 autorů
    Genetic Diversity of Serine Protease Inhibitors in Myxozoan (Cnidaria, Myxozoa) Fish Parasites.
    Microorganisms. Roč. 8, č. 10 (2020), č. článku 1502. E-ISSN 2076-2607
    Grant CEP: GA MŠMT(CZ) LTAUSA17201; GA ČR(CZ) GX19-28399X
    Institucionální podpora: RVO:60077344
    Klíčová slova: proteinase-inhibitors * serpins * host * conservation * superfamily * mechanism * invasion * database * genome * serpins * microscopic parasite * free-living Cnidaria * phylogeny * signature * conserved domains * therapeutic target
    Obor OECD: Microbiology
    Impakt faktor: 4.128, rok: 2020
    Způsob publikování: Open access
    https://www.mdpi.com/2076-2607/8/10/1502

    We studied the genetic variability of serine protease inhibitors (serpins) of Myxozoa, microscopic endoparasites of fish. Myxozoans affect the health of both farmed and wild fish populations, causing diseases and mortalities. Despite their global impact, no effective protection exists against these parasites. Serpins were reported as important factors for host invasion and immune evasion, and as promising targets for the development of antiparasitic therapies. For the first time, we identified and aligned serpin sequences from high throughput sequencing datasets of ten myxozoan species, and analyzed 146 serpins from this parasite group together with those of other taxa phylogenetically, to explore their relationship and origins. High intra- and interspecific variability was detected among the examined serpins. The average sequence identity was 25-30% only. The conserved domains (i.e., motif and signature) showed taxon-level differences. Serpins clustered according to taxonomy rather than to serpin types, and myxozoan serpins seemed to be highly divergent from that of other taxa. None of them clustered with their closest relative free-living cnidarians. The genetic distinction of myxozoan serpins further strengthens the idea of an independent origin of Myxozoa, and may indicate novel protein functions potentially related to parasitism in this animal group.
    Trvalý link: http://hdl.handle.net/11104/0315064

     
     
Počet záznamů: 1  

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