Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes

0537152 - BC 2021 RIV GB eng J - Článek v odborném periodiku
Aphasizheva, I. - Alfonzo, J. D. - Carnes, J. - Cestari, I. - Cruz-Reyes, J. - Goeringer, H.U. - Hajduk, S. - Lukeš, Julius - Madison-Antenucci, S. - Maslov, D. - McDermott, S.M. - Ochsenreiter, T. - Read, L. K. - Salavati, R. - Schnaufer, A. - Schneider, A. - Simpson, L. - Stuart, K. - Yurchenko, V. - Zhou, Z. H. - Zíková, Alena - Zhang, L. - Zimmer, S. - Aphasizhev, R.
Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.
Trends in Parasitology. Roč. 36, č. 4 (2020), s. 337-355. ISSN 1471-4922. E-ISSN 1471-5007
Grant CEP: GA MŠMT(CZ) EF16_019/0000759; GA MŠMT(CZ) LL1601
Institucionální podpora: RVO:60077344
Klíčová slova: pentatricopeptide repeat proteins * editing-associated protein-1 * uridylyl transferase tutase * editosome-like complex * blood-stream form * life-cycle stages * messenger-rna * guide-rna * binding complex * leishmania-tarentolae
Obor OECD: Developmental biology
Impakt faktor: 9.014, rok: 2020
Způsob publikování: Open access
https://www.sciencedirect.com/science/article/pii/S1471492220300167?via%3Dihub

Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs (rRNAs) and proteins and minicircles bearing guide RNAs (gRNAs) for mRNA editing. All RNAs are produced by a phage-type RNA polymerase as 3' extended precursors, which undergo exonucleolytic trimming. Most pre-mRNAs proceed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing. The rRNAs and gRNAs are 3' uridylated. Historically, RNA editing has attracted major research effort, and recently essential pre- and postediting processing events have been discovered. Here, we classify the key players that transform primary transcripts into mature molecules and regulate their function and turnover.
Trvalý link: http://hdl.handle.net/11104/0314902