0537121 - MBÚ 2021 RIV US eng J - Článek v odborném periodiku
Hurtová, Martina - Biedermann, David - Kuzma, Marek - Křen, Vladimír
Mild and Selective Method of Bromination of Flavonoids.
Journal of Natural Products. Roč. 83, č. 11 (2020), s. 3324-3331. ISSN 0163-3864. E-ISSN 1520-6025
Grant CEP: GA ČR(CZ) GA18-00150S; GA MŠMT(CZ) LTC20070
Institucionální podpora: RVO:61388971
Klíčová slova: Silybin * Flavonolignans * Silicristin
Obor OECD: Organic chemistry
Impakt faktor: 4.050, rok: 2020 ; AIS: 0.814, rok: 2020
Způsob publikování: Omezený přístup
Web výsledku:
https://pubs.acs.org/doi/10.1021/acs.jnatprod.0c00655DOI: https://doi.org/10.1021/acs.jnatprod.0c00655

A new method was developed for the mild and selective bromination of simple aromatic compounds and flavonoids in good yields using α,β-dibromohydrocinnamic acid in the presence of a base. This procedure enables selective mono- or dibromination of compounds highly sensitive to oxidative or radical attack. New brominated derivatives of silymarin flavonolignans and related flavonoids were prepared. These brominated derivatives can be used as valuable synthetic intermediates in further synthesis.
Trvalý link: http://hdl.handle.net/11104/0314868