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The Anti-Obesogenic Effect of Lean Fish Species Is Influenced by the Fatty Acid Composition in Fish Fillets
- 1.0536897 - FGÚ 2021 RIV CH eng J - Článek v odborném periodiku
Fjaere, E. - Myrmel, L. S. - Dybing, K. - Kuda, Ondřej - Jensen, B. A. H. - Rossmeisl, Martin - Froyland, L. - Kristiansen, K. - Madsen, L.
The Anti-Obesogenic Effect of Lean Fish Species Is Influenced by the Fatty Acid Composition in Fish Fillets.
Nutrients. Roč. 12, č. 10 (2020), č. článku 3038. E-ISSN 2072-6643
Institucionální podpora: RVO:67985823
Klíčová slova: nutrition * seafood * n-3 PUFA * EPA * DHA * phospholipids * endocannabinoids * marine protein source * obesity and mice
Obor OECD: Endocrinology and metabolism (including diabetes, hormones)
Impakt faktor: 5.719, rok: 2020
Způsob publikování: Open access
https://www.mdpi.com/2072-6643/12/10/3038
Fillets from marine fish species contain n-3 polyunsaturated fatty acids (PUFAs) in the form of phospholipids (PLs). To investigate the importance of PL-bound n-3 PUFAs in mediating the anti-obesogenic effect of lean seafood, we compared the anti-obesogenic properties of fillets from cod with fillets from pangasius, a fresh water fish with a very low content of PL-bound n-3 PUFAs. We prepared high-fat/high-protein diets using chicken, cod and pangasius as the protein sources, and fed male C57BL/6J mice these diets for 12 weeks. Mice fed the diet containing cod gained less adipose tissue mass and had smaller white adipocytes than mice fed the chicken-containing diet, whereas mice fed the pangasius-containing diet were in between mice fed the chicken-containing diet and mice fed the cod-containing diet. Of note, mice fed the pangasius-containing diet exhibited reduced glucose tolerance compared to mice fed the cod-containing diet. Although the sum of marine n-3 PUFAs comprised less than 2% of the total fatty acids in the cod-containing diet, this was sufficient to significantly increase the levels of eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) in mouse tissues and enhance production of n-3 PUFA-derived lipid mediators as compared with mice fed pangasius or chicken.
Trvalý link: http://hdl.handle.net/11104/0314649
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