Počet záznamů: 1  

Probiotic from human breast milk, Lactobacillus fermentum, promotes growth in animal model of chronic malnutrition

  1. 1.
    0536684 - MBÚ 2021 RIV US eng J - Článek v odborném periodiku
    Poinsot, P. - Penhoat, A. - Mitchell, M. - Sauvinet, V. - Meiller, L. - Louche-Pelissier, C. - Meugnier, E. - Ruiz, M. - Schwarzer, Martin - Michalski, M.C. - Leulier, F. - Peretti, N.
    Probiotic from human breast milk, Lactobacillus fermentum, promotes growth in animal model of chronic malnutrition.
    Pediatric Research. Roč. 88, č. 3 (2020), s. 374-381. ISSN 0031-3998. E-ISSN 1530-0447
    Institucionální podpora: RVO:61388971
    Klíčová slova: microbiota * cect5716 * nutrition * insights
    Obor OECD: Physiology (including cytology)
    Impakt faktor: 3.756, rok: 2020
    Způsob publikování: Open access
    https://www.nature.com/articles/s41390-020-0774-0

    Background Chronic undernutrition leads to growth hormone resistance and poor growth in children, which has been shown to be modulated by microbiota. We studied whether Lactobacillus fermentum CECT5716 (Lf(CECT5716)), isolated from mother's breast milk, could promote juvenile growth through the modulation of lipid absorption in a model of starvation. Methods Germ-free (GF) Drosophila melanogaster larvae were inoculated with Lf(CECT5716) in conditions of undernutrition with and without infant formula. The impact of Lf(CECT5716) on larval growth was assessed 7 days after egg laying (AED) by measuring the larval size and on maturation by measuring the emergence of pupae during 21 days AED. For lipid absorption test, Caco2/TC7 intestinal cells were incubated with Lf(CECT5716) and challenged with mixed lipid micelles. Results The mono-associated larvae with Lf(CECT5716) were significantly longer than GF larvae (3.7 vs 2.5 mm, p < 0.0001). The effect was maintained when Lf(CECT5716) was added to the infant formula. The maturation time of larvae was accelerated by Lf(CECT5716) (12 vs 13.2 days, p = 0.01). Lf(CECT5716) did not have significant impact on lipid absorption in Caco2/TC7 cells. Conclusions Lf(CECT5716) is a growth-promoting strain upon undernutrition in Drosophila, with a maintained effect when added to an infant formula but without effect on lipid absorption in vitro.
    Trvalý link: http://hdl.handle.net/11104/0314414

     
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.