Translational Research in Serious Human Diseases

0536630 - ÚŽFG 2021 RIV CZ eng M - Část monografie knihy
Vinšová, Johana - Drutovič, Dávid
The role of chromosomal signalling gradients in spindle assembly and chromosome segregation during oocyte meiosis.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 265-271. ISBN 978-80-200-3158-7
Grant CEP: GA MŠMT(CZ) LO1609; GA MŠMT(CZ) LTAUSA17097
Institucionální podpora: RVO:67985904
Klíčová slova: oocyte * spindle * RanGTP
Obor OECD: Reproductive biology (medical aspects to be 3)

Vertebrate reproduction biology is very specific especially when talking about mammals, including humans. In this short review, we are concerned about the oocyte-specific features of meiotic division. Further, we are describing the function of two chromosomal signalling gradients, RanGTP (guanosine triphosphate-bound Ran)-importin β and chromosomal passenger complex during meiosis in different species, their effect on spindle assembly in oocytes and summarizing the latest speculations about more possible functions.
Trvalý link: http://hdl.handle.net/11104/0314376