Translational Research in Serious Human Diseases

0536627 - ÚŽFG 2021 RIV CZ eng M - Část monografie knihy
Koubovská, Markéta - Ďuríček, Tomáš - Šolc, Petr
DNA damage in oocyte during reproductive aging.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 251-256. ISBN 978-80-200-3158-7
Grant CEP: GA MŠMT(CZ) LO1609
Institucionální podpora: RVO:67985904
Klíčová slova: oocytes * ovarian aging * DNA double-strand breaks
Obor OECD: Reproductive biology (medical aspects to be 3)

With the increasing age of a woman, her reproductive capacity decreases, which is mainly due to a loss in an oocyte store in the ovaries and an increasing amount of double-stranded DNA breaks accumulating in the remaining oocytes. Age-related increase in DNA damage in oocytes correlates with decreased expression of DNA repair genes.
Trvalý link: http://hdl.handle.net/11104/0314373