Translational Research in Serious Human Diseases

0536623 - ÚŽFG 2021 RIV CZ eng M - Část monografie knihy
Knoblochová, Lucie - Šolc, Petr
Cell cycle regulation in early embryonic development.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 232-237. ISBN 978-80-200-3158-7
Grant CEP: GA MŠMT(CZ) LO1609; GA ČR(CZ) GA20-27742S
Institucionální podpora: RVO:67985904
Klíčová slova: cell cycle progression * CDK * genomme activation
Obor OECD: Cell biology

Events leading from DNA replication to cell division are called cell cycle progression. The proper coordination of these processes is necessary for ensuring the viability of newly developed cells. This
necessity is very notable in early embryonic divisions, where cell cycle deregulation can lead to serious problems, such as developmental disorders or infertility. This chapter is concerned with cell cycle regulation in general and in the early development of model organisms such as D. melanogaster, X. laevis, D. rerio, and mammals. It focuses on different developmental strategies and the adaptation mechanisms of coordinating cell cycle progression with the genome activation among these species.
Trvalý link: http://hdl.handle.net/11104/0314370