Translational Research in Serious Human Diseases

0536620 - ÚŽFG 2021 RIV CZ eng M - Část monografie knihy
Ďuríček, Tomáš - Šolc, Petr
Embryotransfer.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 218-223. ISBN 978-80-200-3158-7
Grant CEP: GA MŠMT(CZ) LO1609
Institucionální podpora: RVO:67985904
Klíčová slova: embryotransfer * IVF * hormonal stimulation
Obor OECD: Reproductive biology (medical aspects to be 3)

Embryotransfer is one of the most used techniques in assisted reproduction. During embryo transfer, oocytes and sperms are obtained from donors, zygotes (one-cell stage embryos) are produced using in vitro fertilization, and created embryos are placed into the uterus to establish a pregnancy. Alternatively, in animals, zygotes are obtained from female donors already after natural fertilization, and genetic modification is done before embryotransfer. In human medicine, the purpose of embryo transfer is to help give birth to couples, which are subfertile or infertile. With the discovery of gene editing, embryotransfer become a useful technique to obtain model organisms with knock-out or knock-in genes. In this chapter, we summarize the embryotransfer procedure in mice and pigs, two important animal models for biomedical research.
Trvalý link: http://hdl.handle.net/11104/0314368