Translational Research in Serious Human Diseases

0536618 - ÚŽFG 2021 RIV CZ eng M - Část monografie knihy
Miltrová, Veronika - Kupcová Skalníková, Helena
Cytokines in malignant melanoma.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 208-217. ISBN 978-80-200-3158-7
Grant CEP: GA MŠMT(CZ) LO1609; GA MŠMT(CZ) EF16_019/0000785
Institucionální podpora: RVO:67985904
Klíčová slova: cytokines * melanoma * regression
Obor OECD: Oncology

Cutaneous melanoma is a malignant skin disease. Melanoma is a highly immunogenic tumour and patient‘ s own immunity plays an important role in the control of melanoma growth and spreading. Cytokines are small secreted proteins that are not only key regulators of immune reactions but also mediators of intercellular interactions in the melanoma microenvironment. Cytokines have diagnostic, prognostic and therapeutic potential, however additional studies are required to fully understand their regulatory networks. A pig MeLiM model has a potential to help our understanding of immune reactions in melanoma regression.
Trvalý link: http://hdl.handle.net/11104/0314367