Translational Research in Serious Human Diseases

0536538 - ÚŽFG 2021 RIV CZ eng M - Část monografie knihy
Pánková, Tereza - Vodička, Petr
Microbiome-gut-brain axis in pathogenesis of neurodegenerative diseases.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 132-140. ISBN 978-80-200-3158-7
Grant CEP: GA MŠMT(CZ) LO1609
Institucionální podpora: RVO:67985904
Klíčová slova: microbiome * neurodegenerative diseases * Huntington disease
Obor OECD: Biochemistry and molecular biology

From the very beginning of our lives, our gut is colonized by a complex of commensal, symbiotic and pathogenic microorganisms. Changes in development and composition of microbial communities can be a potential risk for many diseases, surprisingly including neurodegenerative illnesses. Bidirectional communication between central neural system and gastrointestinal system, called gut-brain axis, plays an important role in this phenomenon. Huntington disease is a hereditary neurodegeneration characterized by motor, cognitive, psychiatric changes, and metabolic dysfunction, e.g. weight loss. This review briefly discusses the gut-brain axis hypothesis and on example of HD gives short overview of possible involvement of gut microbiome in progress of neurodegenerations.
Trvalý link: http://hdl.handle.net/11104/0314309