Translational Research in Serious Human Diseases

0536506 - ÚŽFG 2021 RIV CZ eng M - Část monografie knihy
Vodičková Kepková, Kateřina - Vodička, Petr
Genetic causes and animal models of basal ganglia related disorders - II. Neuropsychiatric disorders.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 76-91. ISBN 978-80-200-3158-7
Grant CEP: GA MŠMT(CZ) LO1609
Institucionální podpora: RVO:67985904
Klíčová slova: striatum * neuropsychiatric disorders * CBGTC loops
Obor OECD: Biochemistry and molecular biology

The striatum serves as an integration hub and relay in a complex information exchange among other parts of brain. Cortico-basal ganglia-thalamo-cortico (CBGTC) loops are involved in regulation of behaviour, and thus their disturbances play an important role across a range of neuropsychiatric disorders. This review provides short overview of several of these disorders and how dysfunction of striatal circuits relates to their pathology. Relevant pharmacological, genetic and environmental animal models available for translational research of these diseases are briefly described.
Trvalý link: http://hdl.handle.net/11104/0314282