Composite 5-methylations of cytosines modulate i-motif stability in a sequence-specific manner: Implications for DNA nanotechnology and epigenetic regulation of plant telomeric DNA

0536135 - BFÚ 2021 RIV NL eng J - Článek v odborném periodiku
Školáková, Petra - Badri, Z. - Foldynová-Trantírková, Silvie - Ryneš, J. - Šponer, Jiří - Fojtová, Miloslava - Fajkus, Jiří - Marek, R. - Vorlíčková, Michaela - Mergny, Jean-Louis - Trantírek, L.
Composite 5-methylations of cytosines modulate i-motif stability in a sequence-specific manner: Implications for DNA nanotechnology and epigenetic regulation of plant telomeric DNA.
Biochimica et Biophysica Acta-General Subjects. Roč. 1864, č. 9 (2020), č. článku 129651. ISSN 0304-4165. E-ISSN 1872-8006
Grant CEP: GA MŠMT EF15_003/0000477; GA ČR(CZ) GA19-17063S
Institucionální podpora: RVO:68081707
Klíčová slova: base-pairing energies * promoter region * g-quadruplex * noncovalent interactions * thermal-stability * molecular switch * rational design
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 3.770, rok: 2020
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S030441652030163X?via%3Dihub

Background: The i-motif is a tetrameric DNA structure based on the formation of hemiprotonated cytosinecytosine (C+.C) base pairs. i-motifs are widely used in nanotechnology. In biological systems, i-motifs are involved in gene regulation and in control of genome integrity. In vivo, the i-motif forming sequences are subjects of epigenetic modifications, particularly 5-cytosine methylation. In plants, natively occurring methylation patterns lead to a complex network of C+.C, C-5m(+).C and C-5m(+).C-5m base-pairs in the i-motif stem. The impact of complex methylation patterns (CMPs) on i-motif formation propensity is currently unknown.
Trvalý link: http://hdl.handle.net/11104/0313957