Mitochondrial complex II and reactive oxygen species in disease and therapy

0535930 - BTÚ 2021 RIV GB eng J - Článek v odborném periodiku
Váňová Hadrava, Kateřina - Kraus, Michal - Neužil, Jiří - Rohlena, Jakub
Mitochondrial complex II and reactive oxygen species in disease and therapy.
Redox Report. Roč. 25, č. 1 (2020), s. 26-32. ISSN 1351-0002. E-ISSN 1743-2928
Grant CEP: GA ČR GA19-20553S; GA ČR(CZ) GA20-18513S; GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:86652036
Klíčová slova: Respiratory complex II * succinate dehydrogenase * reactive oxygen species
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 4.412, rok: 2020
Způsob publikování: Open access
https://www.tandfonline.com/doi/pdf/10.1080/13510002.2020.1752002?needAccess=true&

Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact on the development of pathophysiological conditions, i.e. cancer and neurodegenerative diseases. While the basic framework of CII involvement in ROS production has been defined, the fine details still await clarification. It is important to resolve these aspects to fully understand the role of CII in pathology and to explore its therapeutic potential in cancer and other diseases.
Trvalý link: http://hdl.handle.net/11104/0313803