Electrophoretically Deposited Layers of Octahedral Molybdenum Cluster Complexes: A Promising Coating for Mitigation of Pathogenic Bacterial Biofilms under Blue Light

0535532 - ÚACH 2021 RIV US eng J - Článek v odborném periodiku
Kirakci, Kaplan - Nguyen, T. K. N. - Grasset, F. - Uchikoshi, T. - Zelenka, J. - Kubát, Pavel - Ruml, T. - Lang, Kamil
Electrophoretically Deposited Layers of Octahedral Molybdenum Cluster Complexes: A Promising Coating for Mitigation of Pathogenic Bacterial Biofilms under Blue Light.
ACS Applied Materials and Interfaces. Roč. 12, č. 47 (2020), s. 52492-52499. ISSN 1944-8244. E-ISSN 1944-8252
Grant CEP: GA ČR(CZ) GA19-09721S
Grant ostatní: AV ČR(CZ) StrategieAV21/10
Program: StrategieAV
Institucionální podpora: RVO:61388980 ; RVO:61388955
Klíčová slova: biofilm * electrophoretic deposition * luminescence * molybdenum cluster complex * phototoxicity * singlet oxygen
Obor OECD: Inorganic and nuclear chemistry; Physical chemistry (UFCH-W)
Impakt faktor: 9.229, rok: 2020
Způsob publikování: Omezený přístup
https://pubs.acs.org/doi/10.1021/acsami.0c19036

The fight against infective microorganisms is becoming a worldwide priority due to serious concerns about the rising numbers of drug-resistant pathogenic bacteria. In this context, the inactivation of pathogens by singlet oxygen, O2(1Δg), produced by photosensitizers upon light irradiation has become an attractive strategy to combat drug-resistant microbes. To achieve this goal, we electrophoretically deposited O2(1Δg)-photosensitizing octahedral molybdenum cluster complexes on indium-tin oxide-coated glass plates. This procedure led to the first example of molecular photosensitizer layers able to photoinactivate bacterial biofilms. We delineated the morphology, composition, luminescence, and singlet oxygen formation of these layers and correlated these features with their antibacterial activity. Clearly, continuous 460 nm light irradiation imparted the layers with strong antibacterial properties, and the activity of these layers inhibited the biofilm formation and eradicated mature biofilms of Gram-positive Staphylococcus aureus and Enterococcus faecalis, as well as, Gram-negative Pseudomonas aeruginosa and Escherichia coli bacterial strains. Overall, the microstructure-related oxygen diffusivity of the layers and the water stability of the complexes were the most critical parameters for the efficient and durable use. These photoactive layers are attractive for the design of antibacterial surfaces activated by visible light and include additional functionalities such as the conversion of harmful UV/blue light to red light or oxygen sensing.
Trvalý link: http://hdl.handle.net/11104/0313537